Date: August 27, 2006
Location: Lexington, Kentucky
Aircraft: Canadair CRJ-200ER
Reg: N431CA
Airline: Comair
Flight No: 5191
Fatalities: 50 : 49

The crew took off from the wrong and too short a runway, ran through the airport perimeter fence and impacted trees on an adjacent horse farm and burst into flames. The copilot was the only survivor.